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APLASTIC ANEMIA

APLASTIC ANEMIA TREAMENT IN PAKISTAN

Aplastic anemia is a disease of the bone marrow. It happens when the bone marrow stops making enough red blood cells, white blood cells, and platelets for the body.
It can be moderate, severe, or very severe. People with severe or very severe. It is at risk for life-threatening infections or bleeding.
With prompt and proper care, many people who have this disease can be successfully treated. Many drugs are available which can help cure this and improve blood counts. Blood and marrow stem cell transplants may offer a cure for some people who have it.

What causes Aplastic anemia?

It is caused by the destruction of the blood-forming stem cells in your bone marrow.
Most research suggests that stem cell destruction occurs because the body’s immune system attacks its own cells by mistake.
So, Aplastic anemia causes are generally thought to be an autoimmune disease.
About 75 out of 100 cases of acquired Aplastic anemia are idiopathic. This means they have no known cause.

Hereditary Aplastic anemia:

Hereditary Aplastic anemia —–is passed down through the genes from parent to child. It is usually diagnosed in childhood and is much less common than acquired this disease. People who develop hereditary. It may have other genetic or developmental abnormalities.
About 25 out of 100 cases of acquired Aplastic anemia can be linked to one of several causes.
These include:
Toxins, such as pesticides, arsenic, and benzene
Radiation and chemotherapy used to treat cancer
Treatments for other autoimmune diseases, such as lupus and rheumatoid arthritis
Pregnancy – sometimes, this aplastic anemia symptoms improves on its own after the woman gives birth to Infectious diseases, such as hepatitis, Epstein-Barr virus, cytomegalovirus (si-to-MEG-ah-lo-VI-us), parvovirus B19, and HIV.
Sometimes, cancer from another part of the body can spread to the bone and cause this disease.

APLASTIC ANEMIA: TREATMENT

The main goal of Aplastic anemia treatment is to increase the number of healthy cells in your blood. When your blood counts go up:
You are less likely to need blood from a donor (transfusion)
Your quality of life gets better
Your symptoms are not as bad

WHO NEEDS TREATMENT

People who have mild or moderate may not need treatment of aplastic anemia as long as the condition doesn’t get worse.
who have severe this disease need medical treatment right away to prevent complications.
People who have very severe anemia need emergency medical care in a hospital. Very severe Aplastic anemia can be fatal if it’s not treated right away.
Removing a known cause of this disease, such as exposure to a toxin, also may cure the condition.
THERE ARE THREE CATEGORIES OF TREATMENT FOR APLASTIC ANEMIA
The main goal of Aplastic anemia treatment is to increase the number of healthy cells in your blood.

When your blood counts go up:

Supportive care is a term used for treatments that help you manage the symptoms of this disease and is not a cure.
This approach includes the use of:
Blood transfusions
Iron chelation therapy to treat iron overload
Growth factors
Antibiotics
Immunosuppressive drug therapy lowers your body’s immune response.

Bone marrow transplant

Bone marrow transplant is performed under the supervision of highly professional  Dr & staff. This prevents your immune system from attacking your bone marrow, lets stem cells grow back, and raises blood counts. In the acquired treatment of anemia, immunosuppressive therapy with anti-thymocyte globulin (ATG) plus cyclosporine is the therapy of choice for older patients. It is also used for patients who do not have a matched stem cell donor. About 8 out of 10 patients have a positive response to this treatment. For patients with  (SAA), who have had an insufficient response to immunosuppressive therapy and who are not candidates for a stem cell transplant Promacta ® (Eltrombopag) is approved for use. Eltrombopag works by helping to increase the production of blood cells.

Stem Cell Transplantation:

A stem cell transplantation replaces damaged stem cells with healthy ones from another person (a donor) Stem cell transplants may cure this swear disease in people who can have this type of treatment. The transplant works best in children and young adults with severe this disease who are in good health and who have matched donors.