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(MDS)

MYELODYSPLASTIC SYNDROMES

MYELODYSPLASTIC SYNDROMES (MDS)

MDS is a group of disorders where your bone marrow does not work well, and the blood-forming stem cells in your bone marrow fail to make enough healthy blood cells. People with MDS can lack the right amount of red blood cells, white blood cells, and platelets (the small cells that help blood to clot).
The disease happens because the bone marrow cells do not develop into mature blood cells. Instead, these blood cells stay within the bone marrow in an immature state. The symptoms and the course of MDS may vary greatly from person to person. These differences depend on which blood cells are affected.
All people with MDS have two things in common:
They have a low blood cell count for at least 1 blood cell type. This is called cytopenia.
Their bone marrow and blood contain blood cells with an abnormal shape, size, or look.

What does the term “Myelodysplastic” actually mean?

Myelo = blood cells and Dysplastic = abnormal development or growth. So, when you have Myelodysplastic syndrome, this means that your blood cells have an unusual shape and that they have abnormal growth.

What causes MDS?

Often times, WE don’t know the exact cause of MDS. These cases are called de novo MDS. We do know that certain lifestyle factors are linked to MDS. MDS cannot be passed down through the genes from parent to child and it cannot be passed through germs from person to person.

You are more likely to develop MDS if you have:
Been a smoker
Been heavily exposed to certain chemicals, such as benzene
Had chemotherapy or radiation treatments. These can cause treatment-related or secondary MDS.
Treatment-related MDS is often severe and can be more difficult to treat than de novo MDS. Approximately 90% of people with myelodysplastic syndrome have what is called, “de novo” MDS, meaning it arises without any known cause. A minority of people with MDS have a bone marrow condition that came about as a result of therapies for other cancers – what we call therapy-related.

TREATMENT OF MDS

It depends on the type of MDS and its severity .It could be
Blood transfusion
Mild Chemotherapy
Growth factors to stimulate the bone marrow
In young patients, Bone marrow transplant is an option.