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VON WILLEBRAND DISEASE

VON WILLEBRAND DISEASE TREATMENT IN PAKISTAN

Most common hereditary bleeding disorder

Von Willebrand Disease Treatment

Von Willebrand Disease (VWD) is the most common hereditary bleeding disorder, with an estimated prevalence ranging upward to 1% of the general population. Males and females are both approximately equally affected. VWD arises from a deficiency or dysfunction of the von Willebrand factor (VWF).

Von Willebrand Disease Diagnosis 

The best place for patients with bleeding complications to be Von Willebrand disease diagnosis and managed is at one of the federally-funded hemophilia treatment centers (HTCs) that are spread during the country. HTCs provide complete care from experienced hematologists and other professional teams, including nurses, physical therapists, social workers, and sometimes doctors, dieticians, and other healthcare providers.

Symptoms:

People with Von Willebrand disease symptoms experience frequent nosebleeds, easy bruising, and excessive bleeding through and after invasive methods, such as tooth removals and surgery. Women often experience heavy menstrual bleeding (heavy menstrual sessions that last longer than average) and hemorrhaging after birth.

Types:

TYPE 1

VWD is a partial quantitative deficiency of normally functioning VWF. It is the most common variant, accounting for approximately 75% of symptomatic individuals, and is generally associated with mild bleeding symptoms. Type 2 VWD is a qualitative deficiency due to abnormal function of VWF. It accounts for nearly all the remaining affected individuals

TYPE 2

It has further subtypes including 2A, 2B, 2M, and 2N. These subtypes are characterized by where the abnormal function occurs within the VWF. Of the subtypes, 2A is the most common.

TYPE 3

VWD is the rarest of the variants and is estimated to only affect 1 in 1,000,000 individuals. It arises from the virtual absence of VWF protein and can be associated with severe bleeding symptoms.

MANAGEMENT OF VWD

We use medications to increase plasma level of VWF and factor 8. We sometimes use plasma transfusion and factors to increase levels. Medications are used to decrease the risk of bleeding. Specific of management of VWD with AVWS, menorrhagia, hemorrhagic ovarian cysts, pregnancy and childbirth IS ALSO NEEDED UNDER EXPERT SUPERVISION.